Published Research

Some recent papers published by ICORD researchers are listed below. Links to each of our researchers’ most recent publications are included at the bottom of their respective researcher profile.

A longitudinal study of the neurologic safety of acute baclofen use after spinal cord injury.

Authors: Cragg JJ, Tong B, Jutzeler CR, Warner FM, Cashman N, Geisler F, Kramer JLK.
Published in: Neurotherapeutics. 2019 Feb 5. doi: 10.1007/s13311-019-00713-8
About: This longitudinal study demonstrated that baclofen use within 4 weeks of acute spinal cord injury was associated with higher rates of marked neurological recovery.

Cognitive function after spinal cord injury: a systematic review.

Authors: Sachdeva R, Gao F, Chetwyn CHC, Krassioukov AV.
Published in: Neurology. 2018 Sept 5. doi: 10.1212/WNL.0000000000006244
About: This systematic review reports a high volume of evidence for substantial cognitive impairment in individuals with SCI, and recommends that future studies address the potential secondary causative factors for cognitive impairment in this condition.

Association of Epidural Stimulation With Cardiovascular Function in an Individual With Spinal Cord Injury.

Authors: West CR, Phillips AA, Squair JW, Williams AM, Walter M, Lam T, Krassioukov AV.
Published in: JAMA Neurol. 2018 Feb 19. doi: 10.1001/jamaneurol.2017.5055
About: This study is one of first to have demonstrated that lumbosacral epidural electrical stimulation, which had previously been used to facilitate supra spinal control of the limbs, could also facilitate the restoration of cardiovascular function in people with SCI.

Evidence-based scientific exercise guidelines for adults with spinal cord injury: an update and a new guideline.

Authors: Martin Ginis KA, van der Scheer JW, Latimer-Cheung AE, Barrow A, Bourne C, Carruthers P, Bernardi M, Ditor DS, Gaudet S, de Groot S, Hayes KC, Hicks AL, Leicht CA, Lexell J, Macaluso S, Manns PJ, McBride CB, Noonan VK, Pomerleau P, Rimmer JH, Shaw RB, Smith B, Smith KM, Steeves JD, Tussler D, West CR, Wolfe DL, Goosey-Tolfrey VL.
Published in: Spinal Cord. 2017 Oct 25. doi:
About: This study presents the first-ever evidence-based exercise guidelines targeted specifically to adults with SCI, accounting for factors such as upper body overuse, skin breakdown, autonomic dysreflexia, and overheating.

Spinal cord perfusion pressure predicts neurological recovery in acute spinal cord injury.

Authors: Squair JW, Bélanger LM, Tsang A, Ritchie L, Mac-Thiong JM, Parent S, Christie S, Bailey C, Dhall S, Street J, Ailon T, Paquette S, Dea N, Fisher CG, Dvorak MF, West CR, Kwon BK.
Published in: Neurology. 2017 Oct 17. doi: 10.1212/WNL.0000000000004519
About: This study demonstrates that spinal cord perfusion pressure (SCPP) is independently associated with positive neurological recovery in people with acute SCI, suggesting that SCPP can provide useful information on hemodynamic management in acute SCI.

Transient Hypertension after Spinal Cord Injury Leads to Cerebrovascular Endothelial Dysfunction and Fibrosis.

AuthorsPhillips AA, Matin N, Jia M, Squair JW, Monga A, Zheng MMZ, Sachdeva R, Yung A, Hocaloski S, Elliott S, Kozlowski P, Dorrance AM, Laher I, Ainslie PN, Krassioukov AV.
Published in: J Neurotrauma. 2018 Feb 1. doi: 10.1089/neu.2017.5188
About: This study investigated the cerebrovascular effects of transient hypertension, which has been linked with cerebrovascular disease. Chronic repetitive cerebral hyperfusion secondary to transient hypertension induced by autonomic dysreflexia was correlated with a variety of cerebrovascular impairments that were not observed in a model of chronic steady-state hypertension.

A community perspective on bowel management and quality of life after spinal cord injury: the influence of autonomic dysreflexia.

Authors: Inskip JA, Lucci V-EM, McGrath MS, Willms R, Claydon VE.
Published in: J Neurotrauma. 2018 May 1. doi: 10.1089/neu.2017.5343
About: In this survey of 287 people with SCI, it was found that bowel management was a problem for 78%, interfered with personal relationships for 62%, prevented 62% from staying away from home, and, in people with injuries above T7, induced autonomic dysreflexia in 74% of respondents, while 71% of respondents had not changed their bowel care routine for at least five years. These findings demonstrate the need for further studies exploring ways to manage bowel dysfunction among people with SCI.

 A list of our older publications can be found here.