M.Sc. (Master of Health Science), Ph.D in Experimental Medicine (University of British Columbia), Postdoctoral Fellowship (ICORD), Postdoctoral Fellowship (Centre for Heart, Lung and Vascular Health)
Assistant Professor, Department of Cardiac Sciences and Clinical Neurosciences, University of Calgary
Research InterestsAutonomic function; Blood Pressure Control; Cardiovascular health; cerebral blood flow regulation; Neural control; Neurophysiology; Neurovascular coupling
Dr. Phillips’s research focuses on understanding the mechanisms underlying neurovascular regulation, or the brain’s ability to regulate blood pressure, and developing a neurostimulation therapy to restore this ability in people with autonomic dysfunction. Dr. Phillips combines neuroscience with integrated physiology, or the study of processes in the body on different levels, from single cells to the whole body, as a means of investigating cardiovascular function. He is particularly interested in the possibility of using electrical stimulation of the spinal cord to restore autonomic function following spinal cord injury and neurological conditions causing damage to the spinal cord.
In collaboration with ICORD Principal Investigator Drs. Andrei Krassioukov, Chris West, and Tania Lam, Dr. Phillips investigates the effectiveness of electrical stimulation as a treatment for autonomic dysfunction.
Drs. Phillips and Krassioukov collaboratively research the effects of bladder emptying on autonomic dysreflexia, as well as the need for a consistent definition of neurogenic shock, which causes dangerously low blood pressure following spinal cord injury.
Together with ICORD Principal Investigators Drs. Krassioukov, Stacy Elliott, and Piotr Kozlowski, Dr. Phillips studies the effects of transient hypertension, or temporary episodes of high blood pressure, on the development of cerebrovascular disease.
In collaboration with the labs of ICORD PIs Drs. Chris West, Tania Lam, and Andrei Krassioukov, Dr. Phillips discovered that spinal cord stimulation could lead to improved control of blood pressure in people with spinal cord injury (results published in JAMA Neurology).
Techniques employed in the lab:
- Vascular and cardiac ultrasound
- Beat-by-beat blood pressure
- Orthostatic stress testing
- Arterial blood gas reactivity testing
- Surgically implanted and non-invasive neurostimulation modalities
- CLARITY-optimized light-sheet microscopy
- Arterial cannulation
- Spinal cord transection/contusion
- Genetic strains for optogenetic manipulation (Th-Cre, PV-Cre)
Current Opportunities in the Lab
Dr. Phillips currently has openings in his lab. Trainees at the Postdoctoral, graduate, or undergraduate level are encouraged to review this ad and send their CV and a letter of interest to Ms. Courtney Hubl.
- #West CR, #Phillips AA (Co-First Authors), Squair JW, Williams AM, Walter M, Lam T, Krassioukov AV. Association of Epidural Stimulation With Cardiovascular Function in an Individual With Spinal Cord Injury. JAMA Neurol. Published online February 19, 2018. doi:10.1001/jamaneurol.2017.5055
- Squair JW, Field TS, Phillips AA. Journal Club: Relationship between carotid arterial properties and cerebral white matter hyperintensities. Neurology. 2018: 90(7):338-340.
- Phillips AA, Matin N, Jia M, Squair JW, Monga A, Zheng MMZ, Sachdeva R, Yung A, Hocaloski S, Elliott S, Kozlowski P, Dorrance AM, Laher I, Ainslie PN, Krassioukov AV. Transient Hypertension after Spinal Cord Injury Leads to Cerebrovascular Endothelial Dysfunction and Fibrosis. J Neurotrauma. 2018: 35(3):573-581.
- Ruiz IA, Squair JW, Phillips AA, Lukac CD, Huang D, Oxciano P, Yan D, Krassioukov AV. Incidence and Natural Progression of Neurogenic Shock after Traumatic Spinal Cord Injury. J Neurotrauma. 2018 Feb 1;35(3):461-466.
- Phillips AA, Squair JW, Sayenko DG, Edgerton VR, Gerasimenko Y, Krassioukov AV. An Autonomic Neuroprosthesis: Noninvasive Electrical Spinal Cord Stimulation Restores Autonomic Cardiovascular Function in Individuals with Spinal Cord Injury. J Neurotrauma. 2018 Feb 1;35(3):446-451.
- Saleem S, Vucina D, Sarafis Z, H X Lee A, Squair JW, F Barak O, Coombs GB, Mijacika T, Krassioukov AV, Ainslie PN, Dujic Z, Tzeng YC, Phillips AA. Wavelet decomposition analysis is a clinically-relevant strategy to evaluate cerebrovascular buffering of blood pressure after spinal cord injury. Am J Physiol Heart Circ Physiol. 2018 Mar 30 [Epub ahead of print]