Director of Research, Bladder Care Centre, University of British Columbia
Professor, Department of Urologic Sciences, Faculty of Medicine, University of British Columbia
Active Staff, Vancouver General Hospital
Co-Appointment, Department of Healthcare and Epidemiology, Faculty of Medicine, University of British Columbia
Co-Appointment, Department of Anesthesiology, Pharmacology & Therapeutics, Faculty of Medicine, University of British Columbia
Research Interestsneurourology; urinary tract infection; urodynamics; urology
Dr. Stothers is a Principal Investigator at ICORD. She is the Director of Research for the Bladder Care Center at the University of British Columbia and a member of the Active Staff at Vancouver General Hospital. At the University of British Columbia, Dr. Stothers is a Professor in the Department of Urologic Sciences, and she holds Co-Appointments to the Department of Healthcare and Epidemiology and the Department of Anesthesiology, Pharmacology & Therapeutics.
Dr. Stothers and Dr. Ismail Laher from the UBC Department of Pharmacology at UBC have been collaborating to investigate the relationship between estrogen and lower urinary tract function, while allowing graduate students and post-graduate students to study lower urinary tract physiology and gain experience in a clinical setting.
Along with Dr. Andrew Macnab from the Child & Family Research Institute and funded by a grant from the prestigious Bill & Melinda Gates Foundation, Dr. Stothers is currently working on developing a wireless bladder monitoring system for the developing world.
She is also working on a home spinal cord injury monitoring method using telemedicine with Dr. Mark Nigro and Dr. Blayne Welk from the University of Western Ontario.
Dr. Stothers completed a large-scale, randomized trial of cranberry products for prevent of recurrent urinary tract infections (UTIs) in women, supporting the conclusion that cranberry tablets appeared to be the most cost-effective prevention for UTIs.
Dr. Stothers compared factors pertaining to live donor kidney transplant (LDKT) between nondonors and live kidney donors, uncovering previously unavailable information for health care workers who design donor recruitment for donors of different ethnic origins. They discovered that increasing knowledge about LDKT might not necessarily lead to increase donation. Dr. Stothers and her colleague suggest that a focus on the recipient should be made initially when educating a potential donor, and that potential donors might benefit from speaking with a former kidney donor.
Between 2008 and 2009, Dr. Stothers and her colleagues provided the first alternative to invasive pressure monitoring for the classification of degrees of lower urinary tract obstruction in men.
She is the founding inventor on the use of Near-Infrared Spectroscopy (NIRS) on the bladder and other targets in the pelvis, a considerably less invasive and less costly alternative to older urodynamics methods, while providing even richer information about bladder physiology. The NIRS machines are currently at the clinical trials stage.
For more of her major findings, please see the selected papers below, as well as her recent publications listed at the bottom of the page:
- Vaginal wall sling for anatomical incontinence and intrinsic sphincter dysfunction: Efficacy and outcome analysis
- Delayed hypersensitivity and systemic arthralgia following transurethral collagen injection for stress urinary incontinence
- A randomized trial to evaluate effectiveness and cost effectiveness of naturopathic cranberry products as prophylaxis against urinary tract infection in women
- Reliability, validity and gender differences in the quality of life index of the SEAPI-QMM incontinence classification system
- A review of the L-arginine-nitric oxide-guanylate cyclase pathway as a mediator of lower urinary tract physiology and symptoms
Techniques employed in the lab:
- Near Infrared Spectroscopy
Affiliation with organizations and societies:
- American Urologic Association (AUA)
- European Urological Association (EUA)
- Fellow Royal College of Physicians and Surgeons of Canada (FRCSC)
- International Consultation on Incontinence, World Health Organization (WHO)
Some of Dr. Stother’s recent major awards and accomplishments include:
- Best Original Research by a Member – Second Prize (Northwest Urologic Society, 2015)
- First Place Ribbon, Section Urodynamics (American Urologic Association, 2010)
- Harry Cooper Award for Research (Northwest Urologic Society, 2007)
- Special Merit for Research (UBC, 2007)
- Women of Distinction Nominee (YWCA, 2005, 2006)
- Outstanding Researcher Award (UBC, 1998-1999)
Current Lab Members
|Masters Students||Ph.D. Students|
|Emily Deegan||Marwa Abdulaziz|
Current Opportunities in the Lab
Please contact Dr. Stothers with inquiries.
- Stothers, L, Macnab, AJ, Bajunirwe, F, Mutabazi, S, Berkowitz, J. 2017. Associations between the severity of obstructive lower urinary tract symptoms and care-seeking behavior in rural Africa: A cross-sectional survey from Uganda.. PLoS ONE. doi: 10.1371/journal.pone.0173631.
- Stothers, L, Mutabazi, S, Mukisa, R, Macnab, AJ. 2017. The burden of bladder outlet obstruction in men in rural Uganda.. Int J Epidemiol. doi: 10.1093/ije/dyw285.
- Stothers, L, Tsang, B, Nigro, M, Lazare, D, Macnab, A. 2016. An integrative review of standardized clinical evaluation tool utilization in anticholinergic drug trials for neurogenic lower urinary tract dysfunction.. Spinal Cord. doi: 10.1038/sc.2016.63.
- Fougere, RJ et al.. 2016. Reduction in Bladder-Related Autonomic Dysreflexia after OnabotulinumtoxinA Treatment in Spinal Cord Injury.. J. Neurotrauma. doi: 10.1089/neu.2015.4278.
- Larouche, M et al.. 2016. Mid-urethral slings on YouTube: quality information on the internet?. Int Urogynecol J. doi: 10.1007/s00192-015-2908-1.