Dr. David Granville

Principal Investigator

B.Sc. [Biological Sciences] (Simon Fraser University)
Ph.D. [Experimental Pathology] (University of British Columbia)
Postdoctoral Fellowship [Molecular and Experimental Medicine] (Scripps Research Institute)
Professor, Pathology and Laboratory Medicine, UBC

Scholar of the Royal Society of Canada
Associate Director, Vancouver Coastal Health Research Institute (VCHRI)
Associate Director, BC Professional Firefighters’ Burn and Wound Healing Research Laboratory, Division of Plastic Surgery, Department of Surgery, UBC
Principal Investigator, UBC Centre for Heart Lung Innovation, St. Paul’s Hospital
Associate Member, Department of Surgery, UBC
Affiliated Member, CIHR Skin Research Training Centre, UBC
Adjunct Professor, Institute of Molecular Biology and Biochemistry, Simon Fraser University
Founder and Chief Scientific Officer, viDA Therapeutics Inc.

Research Interests

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Over the past 20 years, Dr. Granville’s research program has focused on identifying mechanisms that underlie tissue injury and therapeutic targets that can be exploited to reduce injury and/or promote healing. His research is presently centered on how aging and immobility affect tissue injury, inflammation, and repair in different types of tissues. Dr. Granville’s research team is investigating a family of immune cell-secreted proteases known as granzymes (granule-secreted enzymes) and their role in aging and chronic inflammation. Dr. Granville identified that granzymes are elevated and contribute to the pathogenesis of conditions associated with impaired healing and inflammation, including skin injuries, autoimmune skin diseases, and cardiovascular and pulmonary diseases. In order to study granzymes in a diverse set of indications, Dr. Granville collaborates with a network of expert clinical and scientific collaborators. Dr. Granville is currently translating his discoveries into the development and commercialization of novel, first-in-class therapeutics.

At ICORD, Dr. Granville’s team is expanding on their discoveries in tissue injury, inflammation, and repair, and applying their expertise to spinal cord injury, pressure injury, dermatological conditions, and aging-related disorders. Dr. Granville also continues to lead an established research program examining the role of granzymes in cardiovascular and pulmonary diseases. Dr. Granville’s team is currently one of few groups in the world studying granzyme K in inflammation and disease.

Major Findings:

In his early career (1994-2001), he worked at QLT Inc. (Vancouver, BC), where his research supported the development and approval of Visudyne® as the first treatment for age-related macular degeneration, the leading cause of blindness in the elderly. In 1999, Visudyne® was approved by the FDA, resulting in the largest ophthalmic product release in history at the time. Dr. Granville’s research is referred to on the drug label for Visudyne® and he is listed as a primary inventor on patents pertaining to his work at QLT. In 2001, Dr. Granville relocated to the Scripps Research Institute (La Jolla, CA), where he identified a novel therapeutic approach for attenuating cardiac ischemia and reperfusion injury. Dr. Granville is a primary inventor on patents pertaining to the latter discoveries that led to the formation of Radical Therapeutix Inc (San Diego, CA). Dr. Granville was recruited back to UBC in 2003 as a Canada Research Chair and Michael Smith Foundation for Health Research Scholar.

At UBC, Dr. Granville’s laboratory has been a significant contributor to challenging the existing dogma that granzymes (granule-secreted enzymes) function solely as an intracellular mediator of lymphocyte-induced targeted cell death. His team was first to demonstrate a novel extracellular role for granzyme B in a disease model. Dr. Granville’s group has since discovered pathogenic roles for granzyme B in aging, chronic inflammation, tissue injury, and repair. In particular, discoveries pertaining to granzyme B in skin frailty, wound healing, and blistering have led to the formation of viDA Therapeutics. Together with viDA, the UBC Centre for Drug Research and Development (now adMare Bioinnovations), and other clinical specialists, Dr. Granville is developing and testing novel first-in-class therapeutics for both autoimmune and chronic inflammatory conditions of the skin, with a goal of entering the clinic by 2021. Dr. Granville’s research has resulted in the filing of 44 patents, of which all are owned by UBC and/or licensed to industry, and all include his trainees as co-inventors. He is also the Scientific Founder and Chief Scientific Officer of the UBC spin-off company, viDA Therapeutics, Inc.

Notable Publications:

Techniques Employed and Fields of Study in the Lab:

  • Molecular biology
  • Biochemistry
  • Histology
  • Immunohistochemistry
  • Microscopy
  • Primary cell culture
  • Wound healing assays
  • Migration assays
  • Epithelial barrier function
  • Endothelial permeability
  • Apoptosis
  • Extracellular matrix remodeling
  • Inflammation
  • Vascular function
  • Disease modelling (aneurysm, atherosclerosis, ischemia/reperfusion, vascular leakage, airway inflammation, acute/chronic wound healing, burn, frostbite, fibrosis, scarring, pressure injury, autoimmune skin diseases)
  • Preclinical validation
  • Drug discovery

Affiliations with Organizations:

  • BC Professional Firefighters’ Burn and Wound Healing Research Laboratory
  • adMare Bioinnovations (formerly Centre for Drug Research and Development), UBC
  • Centre for Heart Lung Innovation, UBC
  • Departments of Pathology and Surgery, UBC
  • viDA Therapeutics, Inc.

Awards:

Some of Dr. Granville’s major awards and accomplishments include:

  • Tier II Canada Research Chair
  • Michael Smith Foundation for Health Research Scholar
  • Young Investigator Award, Canadian Society of Transplantation
  • Wilbert J. Keon Award for Basic Science Finalist
  • Canada Top 40 Under 40 Award
  • Outstanding Young Alumnus Award, University of British Columbia
  • American Heart Association – Louis N and Arnold M Katz Basic Science Research Prize Finalist
  • Outstanding Alumni Award for Academic Achievement, Simon Fraser University
  • Canadian Association of Pathologists Junior Scientist Award
  • Business in Vancouver Forty Under 40 Award
  • Fellow of the American Heart Association
  • Scholar of the College of New Scholars, Artists and Scientists of the Royal Society of Canada

Current Lab Members:

Masters Students Ph.D. Students Postdoctoral Fellows Research Staff Administrative Staff
Keerit Tauh Katlyn Richardson Dr. Chris Turner Hongyan Zhao Karen Jung
Anna-Catharina Wilhelm Dr. Matthew Zeglinski
Dr. Sho Hiroyasu
Dr. Lara Utsch Mendes Gouveia

Trainee Awards:

Year Trainee Award
2020 Chris Turner Top Young Investigator Award, Wound Healing Society

Travel Award, Wound Healing Society

Travel Award, Australasian Wound and Tissue Repair Society

Travel Award, BC Regenerative Medicine Cluster

2019 Chris Turner Co-Applicant, ICORD Seed Grant

Top Young Investigator Award, Wound Healing Society

Travel Award, Skin Research Group of Canada

Travel Award, Wound Healing Society

Travel Award, ICORD

Travel Award, Australasian Wound and Tissue Repair Society (AWTRS)

Travel Award, BC Regenerative Medicine Cluster

Matthew Zeglinski 1st Place, ImmunoBC Speed Talk

UBC Science Co-op Supervisor Recognition Award

Sho Hiroyasu Best Scientific Paper, UBC Plastic Surgery Research Day

Top Post-Doctoral Fellow Abstract, UBC Pathology Day

Travel Award, ICORD

Katlyn Richardson Department Nominee, Vanier Canada Graduate Scholarships

Canada Graduate Scholarship Masters Award

Trainee Travel Award, The Histochemical Society Experimental Biology Conference

Travel Award, Skin Research Group of Canada

Travel Award, ICORD

Top Presentation, UBC Skin Care Research Workshop

Best Oral Presentation, Skin Research Group of Canada

Best Oral Presentation, ICORD Trainee Research Day

People’s Choice Top Oral Presentation, UBC Faculty of Medicine Research Day

2018 Chris Turner CIHR Travel Award from the Institute of Aging

Top Science Presentation at UBC Plastic Surgery Day

Travel Award from Wound Healing Society

ICORD Trainee Symposium Presentation Award (Senior category)

Australasian Wound and Tissue Repair Society (AWTRS) Conference Award

AWTRS Young Investigator of the Year, Australia

Travel Award (ICORD)

CIHR Postdoctoral Fellowship (CIHR)

Travel Award (American Society for Matrix Biology)

Keerit Tauh Best Poster in Basic Science for the 2018 Canadian Cardiovascular Congress

Travel Award for Circulatory & Respiratory Health (CIHR)

Travel Award (ICORD)

Keir Martyn Top Undergraduate Student Poster Presentation Award at UBC Pathology Day
Sho Hiroyasu Mitacs Postdoctoral Fellowship (Accelerate) with matching funds from RHI
Matthew Zeglinski CIHR Postdoctoral Fellowship (CIHR)

MSFHR Postdoctoral (MSFHR)

Steve Shen Travel Award for Young Investigators (American Heart Association ATVB)

Travel Award (ICORD)

Travel Award (Canadian Society for Atherosclerosis, Thrombosis and Vascular Biology)

Valerio Russo Best Design Poster Award (ICORD SCI Symposium)

Highest Ranked Abstract Award (UBC Pathology and Laboratory Medicine)

Travel Award (American Society for Matrix Biology)

Katlyn Richardson Entrance Scholarship, UBC Graduate Studies

Graduate Award, UBC Faculty of Medicine

Cameron Oram Travel Award (ICORD)
Stephanie Santacruz Travel Award (ICORD)
2017 Cameron Oram Travel Award (ICORD)
Valerio Russo Best Design Poster Award (ICORD SCI Symposium)

Highest Ranked Abstract Award (UBC Pathology and Laboratory Medicine)

Travel Award (American Society for Matrix Biology)

Postdoctoral Fellowship (Mitacs)

Stephanie Santacruz Travel Award (ICORD)
Steve Shen ATVB Travel Award for Young Investigators (Arteriosclerosis, Thrombosis and Vascular Biology)

Travel Award (ICORD)

Keerit Tauh Frederick Banting and Charles Best Canada Graduate Scholarship-Master’s Award (CIHR)

Clinician Investigator Scholarship (UBC Faculty of Medicine)

Chris Turner Travel Award (ICORD)

Postdoctoral Fellowship (CIHR)

Travel Award (American Society for Matrix Biology)

Matthew Zeglinski Postdoctoral Fellowship (CIHR)

Postdoctoral Fellowship (MSFHR)

2016 Valerio Russo IMPACT Award (CIHR)
Steve Shen IMPACT Award (CIHR)

Postdoctoral Fellowship (CIHR)

Stephanie Santacruz Best Poster Award (ICORD AGM)
Chris Turner IMPACT Award (CIHR)
2015 Yulia Merkolova Frederick Banting and Charles Best Canada Graduate Scholarship (CIHR)
Steve Shen  Basic Cardiovascular Sciences Travel Award (American Heart Association)
2014 Paul Hanson Top Poster Award (American Society for Investigative Pathology)
Paul Hiebert Banting Postdoctoral Fellowship (CIHR)
Leigh Parkinson Top Poster Award (American Society for Investigative Pathology)
2013 Alon Hendel Top Poster Award (ImmunoVancouver)
Ivy Hsu Top Poster Prize (UBC Skin Research Day)

Graduate Student Fellowship (UBC Department of Pathology)

2012 Lisa Ang Travel Award (American Society for Matrix Biology)

Oral Presentation Award (American Society for Matrix Biology)

Alon Hendel Top Poster Award (American Society for Matrix Biology)
Paul Hiebert  Top Graduate Student Award (James Hogg Research Centre)
 Ivy Hsu  Skin Research Training Centre Scholar Award (CIHR)
2010 Lisa Ang Frederick Banting and Charles Best Canada Graduate Scholarship (CIHR)

Top Oral Presentation (UBC Pathology Day)

Wendy Boivin  Young Investigator Forum Poster Award (CIHR)Travel Award (American Society for Matrix Biology)
Dawn Cooper Alice Wilson Award of the Royal Society of Canada

Postdoctoral Fellowship (NSERC)

Alon Hendel Jean-Francois Bowden Award (Institute for Heart and Lung Health)

Vanier Canada Graduate Scholarship

Paul Hiebert  Doctoral Fellowship (NSERC)Skin Research Training Centre Scholar Award (CIHR)

Jean-Francois Bowden Award (Institute for Heart and Lung Health)

Top Poster Award (Providence Heart and Lung FEST)

2009 Lisa Ang Travel Award (North American Vascular Biology Organization)

Top Poster Prize, Runner-up (UBC Pathology Day)

Alon Hendel Graduate Scholarship (Pacific Century)

Graduate Research Fellowship (UBC)

Have a Heart Bursary Program Award (Canadian Cardiovascular Society)

Top Junior Poster Presentation (Centre for Blood Research, UBC)

Paul Hiebert Skin Research Training Centre Fellowship (CIHR)

Have a Heart Bursary Program Award (Canadian Cardiovascular Society)

Top Poster Presentation (UBC Pathology Day)

Top Senior Poster Presentation (Centre for Blood Research, UBC)

Arwen Hunter  Postdoctoral Fellowship (Heart and Stroke Foundation of Canada)
Sarah Williams IMPACT Award (CIHR)

Postdoctoral Fellowship (CIHR)

Current Opportunities in the Lab:

Although his laboratory is quite full at the moment, Dr. Granville is always on the lookout for talented, energetic and bright graduate students and post-doctoral fellows to join his team if funding is available. Please contact Dr. Granville with inquiries.

Recent publications

  • Sellers, SL et al.. 2020. Tricuspid Valve-in-Valve and Bioprosthetic Surgical Tricuspid and Pulmonic Valve Degeneration: Lessons From Imaging and Histopathology.. JACC Cardiovasc Imaging. doi: 10.1016/j.jcmg.2020.06.008.
  • Turner, CT et al.. 2020. Granzyme B Contributes to Barrier Dysfunction in Oxazolone-Induced Skin Inflammation through E-Cadherin and FLG Cleavage.. J. Invest. Dermatol. doi: 10.1016/j.jid.2020.05.095.
  • Matsubara, JA et al.. 2020. Retinal Distribution and Extracellular Activity of Granzyme B: A Serine Protease That Degrades Retinal Pigment Epithelial Tight Junctions and Extracellular Matrix Proteins.. Front Immunol. doi: 10.3389/fimmu.2020.00574.
  • Liu, B, Granville, DJ, Golledge, J, Kassiri, Z. 2020. Pathogenic mechanisms and the potential of drug therapies for aortic aneurysm.. Am. J. Physiol. Heart Circ. Physiol. doi: 10.1152/ajpheart.00621.2019.
  • Panwar, P et al.. 2020. Expression of elastolytic cathepsins in human skin and their involvement in age-dependent elastin degradation.. Biochim Biophys Acta Gen Subj. doi: 10.1016/j.bbagen.2020.129544.
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