Dr. Mohammad Javan

Associate Member

B.Sc. (Mashad University), M.Sc. (Shaheed Beheshti University), Ph.D (Shaheed Beheshti University), Postdoctoral Fellowship (Kyorin University School of Medicine)
Professor Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Research Interests

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Dr. Javan is interested in myelin protection, myelin repair, and neurodegeneration following nerve diseases and traumatic neural injuries. Gliosis, or heightened activity of the cells that form myelin, called glia, is a frequent result of spinal cord injury and traumatic head injury, and it impedes neural repair. Dr. Javan’s research involves converting astrocytes and other glial cells located in the injured brain and spinal cord into neurons and OPCs, cells that can become oligodendrocytes. These, in turn, provide insulation to axons, which conduct electrical impulses from nerves. Dr. Javan uses transcription factors and microRNAs to generate neurons and OPCs in order to help repair damaged neural tissue.

Recent collaborations

Dr. Javan is collaborating with Dr. Wolfram Tetzlaff on a research project examining the mechanisms of demyelination-induced axon damage and the possible benefits of antioxidants in this context.

Techniques employed in the lab:

  • Cell fate conversion studies
  • In vivo gene delivery
  • Chemical demyelination models

Affiliation with organizations and societies:

  • International Brain Research Organization (IBRO)
  • International Society for Stem Cell Research (ISSCR)
  • Council Member, Iranian Society of Physiology and Pharmacology
  • Iranian Cell Death Society
  • Iranian Neuroscience Society
  • Royan Institute for Stem Cell Biology and Technology

Current Opportunities in the Lab

Please contact Dr. Javan with inquiries.

Recent publications

  • Shiri, H, Javan, M. 2024. Sox2-mediated transdifferentiation of hAT-MSCs into induced neural progenitor-like cells for remyelination therapies.. Tissue Cell. doi: 10.1016/j.tice.2024.102553.
  • Rayatpour, A, Foolad, F, Javan, M. 2024. Deferiprone promoted remyelination and functional recovery through enhancement of oligodendrogenesis in experimental demyelination animal model.. Naunyn Schmiedebergs Arch Pharmacol. doi: 10.1007/s00210-024-03314-1.
  • Rahdar, M et al.. 2024. Reversal of electrophysiological and behavioral deficits mediated by 5-HT7 receptor upregulation following LP-211 treatment in an autistic-like rat model induced by prenatal valproic acid exposure.. Neuropharmacology. doi: 10.1016/j.neuropharm.2024.110057.
  • Parandavar, E, Shafizadeh, M, Ahmadian, S, Javan, M. 2024. Long-term demyelination and aging-associated changes in mice corpus callosum; evidence for the role of accelerated aging in remyelination failure in a mouse model of multiple sclerosis.. Aging Cell. doi: 10.1111/acel.14211.
  • Anvari, S, Javan, M, Mirnajafi-Zadeh, J, Fathollahi, Y. 2024. Erratum to "Repeated Morphine Exposure Alters Temporoamonic-CA1 Synaptic Plasticity in Male Rat Hippocampus" [Neuroscience 545 (2024) 148-157].. Neuroscience. doi: 10.1016/j.neuroscience.2024.04.007.
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