Dr. John Kramer

Principal Investigator

B.Sc. [Kinesiology] (University of Calgary)
M.Sc. [Neuroscience] (University of Western Ontario)
Ph.D. [Neuroscience] (University of British Columbia)
Assistant Professor, School of Kinesiology, Faculty of Education, University of British Columbia

Research Interests

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Dr. Kramer’s current research interests are focused on understanding the relationships between spinal cord injuries and neuropathic pain. Historically, pain has been measured from “yes or no” scores generated from pinprick stimulation. This approach, however, represents only one way that peripheral touch can be interpreted by the spinal cord sensory pathway. Dr. Kramer has made several important contributions to the validation of a newer technique known as Contact Heat Evoked Potential stimulation (CHEPs). CHEPs provides recordings of electrical signals reaching the brain, allowing complementary information regarding the spinal cord sensory pathway to be identified.

As part of Dr. Kramer’s ongoing research program, advanced neuroimaging and quantitative sensory testing techniques will continue to be developed to better understand how changes in the central nervous system (CNS) relate to the development of neuropathic pain. Using large SCI datasets, he is exploring the relationship between pain, neurological recovery, and other secondary health outcomes (e.g., cardiovascular disease). His research program will enable implementation of novel interventions aimed at improving outcomes and quality of life for people with SCI.

Dr. Kramer is an Assistant Professor with the School of Kinesiology at the University of British Columbia. He majored in Kinesiology for his B.Sc. undergraduate degree major at the University of Calgary, and then turned his focus to neuroscience for graduate research. He obtained a M.Sc. degree from the University of Western Ontario and completed his Ph.D. at the University of British Columbia. Dr. Kramer spent the next two years as a postdoctoral fellow, first at the Spinal Cord Injury Center in Uniklinic Balgrist (University of Zurich, Zurich, Switzerland), and then as a Senior Research Fellow at the Hulse Spinal Cord Injury Laboratory in the Shepherd Center (Atlanta, Georgia, USA).

Dr. Kramer says he enjoys his time at ICORD because of the diverse research interests among principal investigators and trainees.  He adds that “there are not many facilities like ICORD in the world, where international experts are brought together in preclinical and clinical SCI research. With the expertise and facilities all in one building, it is an amazing opportunity to perform the highest level of research.”

Currently recruiting for:

Comparing two ways of measuring pain

Researchers in Dr. John Kramer’s lab want to investigate whether people’s reported pain levels are impacted by different pain measures. They will induce mild levels of pain on your forearms using two different pain measurement protocols. They will ask you Read More...

Spinal Cord Injury research participants’ views on data sharing

Researchers in Dr. John Kramer’s lab are investigating how SCI research participants feel about researchers using their data. Specifically, they are interested in learning more about how SCI research participants feel about data sharing. Data sharing is when the data Read More...

Comparison of laser and contact heat evoked potentials in able-bodied people

Researchers in Dr. John Kramer’s lab are investigating the brain’s response to different painful stimuli: contact-heat and radiant-heat. The brain’s response will be recorded using electroencephalography (EEG). These stimuli are currently used in clinical applications to diagnose nerve-damage (neuropathies), however Read More...

Recent Collaborations:

Dr. Kramer is working closely with Dr. Corree Laule to integrate advanced anatomical MRI into the assessment of damage in the spinal cord after injury. The goal of this collaboration is to leverage Dr. Laule’s experience in the field of Multiple Sclerosis, and translate new imaging techniques into the field of SCI. He hopes to begin collecting data in individuals with SCI in the next few months. He also has collaborations with colleagues at the University Hospital Balgrist in Zurich, Switzerland.

Major Findings:

Dr. Kramer’s research has repeatedly shown that spinal cord sensory pathways can be examined with a variety of quantitative techniques sensitive to minor changes in sensory impairments. Furthermore, his work using evoked potentials has shown improved potential for tracking changes in sensory function corresponding to individual spinal segments.  He is in the process of finalizing plans for his next phase of research efforts with Dr. Corree Laule.

Techniques employed in lab:

  • Electroencephalography (EEG, a technique for measuring electrical activity in the brain)
  • Electrophysiological recordings (e.g., somatosensory and contact heat evoked potentials)
  • Anatomical and functional Magnetic Resonance Imaging
  • Questionnaires to assess neurological function (e.g., International Standards for the Neurological Classification of SCI).

Awards:

Some of Dr. Kramers’s recent major awards and accomplishments include:

  • Scholar, Michael Smith Foundation for Health Research, 2014
  • North American Spine Society, Clinical & Research Travelling Fellowship, 2014
  • Scholar, Clinical Research Pillar, (jointly funded by the Michael Smith Foundation for Health Research and the Rick Hansen Institute), 2014
  • Post-Doctoral Fellowship, International Foundation for Research in Paraplegia, 2011
  • Trainee Award, Rick Hansen Institute, 2008

Current Lab Members

Masters Students Ph.D. Students Doctoral Students Postdoctoral Fellows
Anh Khoa Vo Lyndal Sol Kevin Liu Jacquelyn Cragg
Erin Erskine Jessica Archibald Orozco Freda Warner Catherine Jutzeler
Navid Khosravi

Current Opportunities in Lab:

Interested students should contact Dr. Kramer with inquiries.

Opportunities:

Recent publications

  • Erskine, ELKS et al.. Skilled reaching deterioration contralateral to cervical hemicontusion in rats is reversed by pregabalin treatment conditional upon its early administration.. Pain Rep. doi: 10.1097/PR9.0000000000000749.
  • Liu, H et al.. 2019. Myelin Water Fraction and Intra/Extracellular Water Geometric Mean T2 Normative Atlases for the Cervical Spinal Cord from 3T MRI.. J Neuroimaging. doi: 10.1111/jon.12659.
  • Liu, H et al.. 2019. Myelin Water Atlas: A Template for Myelin Distribution in the Brain.. J Neuroimaging. doi: 10.1111/jon.12657.
  • Hubli, M et al.. 2019. Application of electrophysiological measures in spinal cord injury clinical trials: a narrative review.. Spinal Cord. doi: 10.1038/s41393-019-0331-z.
  • Dvorak, AV et al.. 2019. Rapid myelin water imaging for the assessment of cervical spinal cord myelin damage.. Neuroimage Clin. doi: 10.1016/j.nicl.2019.101896.
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