B.Sc. [Microbiology] (University of Alberta), Ph.D. [Microbiology] (University of British Columbia)
Professor, Department of Pathology and Laboratory Medicine, University of British Columbia
Research InterestsAging; lipid metabolism; Neurodegeneration; neuroscience; pathology
Dr. Wellington’s major research interests are on both genetic and environmental factors that modulate risk for Alzheimer Disease (AD), the most common dementia. An increasingly recognized environment risk factor for dementia includes a history of traumatic brain injury (TBI). Current projects include understanding how injury severity, number of injuries, and age at injury all affect dementia risk, and understanding how the neuropathology and clinical presentation of TBI-related syndromes overlap with classical dementias. Over two million TBIs occur annually in North America, with rapidly increasing public concern over the long-term effects of concussion on brain health during development and aging. Existing animal models of TBI, however, fail to replicate the mechanics of most real-life human TBIs, which are caused by sharp, angular and/or linear accelerations or decelerations of a freely moving intact head.
Working with biomechanical engineers at ICORD, Dr. Wellington and her colleagues have developed a transformative new model of rodent closed head TBI, called CHIMERA (Closed Head Injury Model of Engineered Rotational Acceleration) that was specifically designed to overcome the caveats that limit the translational relevance of existing TBI models. CHIMERA’s innovation lies in its ability to generate, in a biomechanically controlled and reproducible manner, a wide range of TBI severity with completely free head movement, where head motion analyses are integrated with behavioral and neuropathological outcomes.
Current Lab Members
|Master Students||PhD Students||Postdoctoral Fellows||Research Associates||Research Staff|
|Honor Cheung||Jennifer Cooper||Dr. Bethany Kondiles||Sophie Stukas||Anna Wilkinson|
|Tali Romero||Tetiana Poliakova||Dr. Mehwish Anwer||Jianjia Fan||Carlos Barron|
|Mohammad Ghodsi||Dr. Tom Cheng||Megan Harper|
- Poliakova, T, Wellington, CL. 2023. Roles of peripheral lipoproteins and cholesteryl ester transfer protein in the vascular contributions to cognitive impairment and dementia.. Mol Neurodegener. doi: 10.1186/s13024-023-00671-y.
- Cooper, JG et al.. 2023. Age specific reference intervals for plasma biomarkers of neurodegeneration and neurotrauma in a Canadian population.. Clin Biochem. doi: 10.1016/j.clinbiochem.2023.110680.
- Stukas, S et al.. 2023. Pediatric reference intervals for serum neurofilament light and glial fibrillary acidic protein using the Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) cohort.. Clin Chem Lab Med. doi: 10.1515/cclm-2023-0660.
- Tabor, JB et al.. 2023. Use of Biostatistical Models to Manage Replicate Error in Concussion Biomarker Research.. JAMA Netw Open. doi: 10.1001/jamanetworkopen.2023.39733.
- Cheng, WH et al.. 2023. Altered Tau Kinase Activity in rTg4510 Mice after a Single Interfaced CHIMERA Traumatic Brain Injury.. Int J Mol Sci. doi: 10.3390/ijms24119439.