Ph.D. [Medical Biochemistry] (University of Calgary)
Associate Member, Department of Pathology and Laboratory Medicine, University of British Columbia
Professor, Division of Hematology and Oncology, Department of Pediatrics, University of British Columbia
Research InterestsCell Signaling; Myelin; Neuropathic pain; Regeneration
Myelin is a protective coating that ensheathes the nerve fibers (termed axons) which carry information to and from the brain. Its main purpose is to enhance the speed of impulse conduction and to protect axons from unnecessary damage. Myelin can be impaired from traumatic injury or also from diseases like multiple sclerosis and leukodystrophy. In such cases, loss of myelin can lead to paralysis, loss of sensation, of learning impairments; however, work is being done to understand how myelin can be regenerated (a process termed re-myelination) which may help alleviate these negative outcomes.
Dr. Catherine Pallen is highly regarded for her research on cell signaling and understanding the role and mechanism by which a molecule called PTPa (protein tyrosine phosphatase alpha) influences myelination. Her work has shown that PTPa is required for normal growth and maturation of myelin-producing cells and she has developed experimental models to investigate how PTPa functions for myelin repair.
Another area of her research is focused on understanding pain pathways and finding better treatments based on cellular regulation. PTPa is known to be involved in integrin signaling (cell receptors essential for cell processes) and because site-specific phosphorylation of PTP molecules is poorly understood, its role in cell migration, development, survival and immune activation is still being studied. Furthermore, PTPa has been linked to the function of a pain-mediating receptor (N-methyl-D-aspartate, NMDA) and could lead to improved treatments for long-term persistent pain.
Techniques employed in the labs:
- Cell culturing
- Transfection of plasmids and small-interfering RNA
- Immunoblot Assays
- Peptide Microarrays
Some of Dr. Pallen’s recent major awards and accomplishments include:
- Award for Excellence in Mentoring Early Career Faculty (Faculty of Medicine, UBC, 2016)
Current Lab Members
|Masters Students||Ph.D. Students||Post-Doctoral Fellows||Research Staff|
|Cassandra Dawson||Dominik Sommerfeld||Dr. Philip Ly||Jing Wang|
|Lisa Decotret||Arshia Beigi|
|2014||Dr. Philip Ly||
Current Opportunities in the Lab
Please contact Dr. Pallen with inquiries.
- Shih, Y, Ly, PTT, Wang, J, Pallen, CJ. 2017. Glial and Neuronal Protein Tyrosine Phosphatase Alpha (PTPα) Regulate Oligodendrocyte Differentiation and Myelination.. J. Mol. Neurosci. doi: 10.1007/s12031-017-0941-x.
- Khanna, RS, Le, HT, Wang, J, Fung, TC, Pallen, CJ. 2015. The interaction of protein-tyrosine phosphatase α (PTPα) and RACK1 protein enables insulin-like growth factor 1 (IGF-1)-stimulated Abl-dependent and -independent tyrosine phosphorylation of PTPα.. J. Biol. Chem. doi: 10.1074/jbc.M114.624247.
- Geldman, A, Pallen, CJ. 2015. Protein tyrosine phosphatases in mast cell signaling.. Methods Mol. Biol. doi: 10.1007/978-1-4939-1568-2_17.
- Cheng, SY, Sun, G, Schlaepfer, DD, Pallen, CJ. 2014. Grb2 promotes integrin-induced focal adhesion kinase (FAK) autophosphorylation and directs the phosphorylation of protein tyrosine phosphatase α by the Src-FAK kinase complex.. Mol. Cell. Biol. doi: 10.1128/MCB.00825-13.
- Fam, HK et al.. 2013. TDP1 and PARP1 deficiency are cytotoxic to rhabdomyosarcoma cells.. Mol. Cancer Res. doi: 10.1158/1541-7786.MCR-12-0575.