Investigator
B.Sc. [Microbiology and Immunology] (University of British Columbia)
Ph.D. [Pathology & Laboratory Medicine, Neuropathology] (University of British Columbia)
Post-doctorate (National Institutes of Health, NINDS, Bethesda, MD, USA)
Associate Director, UBC Hospital MS Research Program
Assistant Professor, Department of Pathology and Laboratory Medicine, Faculty of Medicine, UBC
Research Interests
Biomarkers; Immunology; Multiple Sclerosis; Neurodegeneration; Neuroprotection; neuroscienceDr. Jacqueline Quandt is the principal investigator and associate director of the UBC Multiple Sclerosis Research Group at UBC and leads the Neuroinflammation Lab at the Djavad Mowafaghian Centre for Brain Health and the Department of Pathology in the Faculty of Medicine. Her research is focused on understanding the role of the immune system in both damage and repair of the brain and spinal cord as a result of neurodegenerative diseases, such as multiple sclerosis (MS). Using cell-based and more complex disease models, researchers in the Quandt Lab study the relationships between inflammation and neuronal death.
The Quandt lab’s current projects are diverse and the studies span both basic and clinical research. Most apply molecular and cellular techniques in cell and disease models to study the way that inflammatory cells contribute to disease development. Having made significant contributions to MS research, the lab is now pursuing discovery in a range of neurodegenerative diseases. Project areas focus on the topic of neuroinflammation as it relates to damage and repair in MS. Other related areas of focus include the immunology of autoimmunity, tolerance, as well as neuroprotection.
Recent publications
- Desu, HL, Sawicka, KM, Wuerch, E, Kitchin, V, Quandt, JA. 2024. A rapid review of differences in cerebrospinal neurofilament light levels in clinical subtypes of progressive multiple sclerosis.. Front Neurol. doi: 10.3389/fneur.2024.1382468.
- Ajaykumar, A et al.. 2023. Dolutegravir-containing HIV therapy reversibly alters mitochondrial health and morphology in cultured human fibroblasts and peripheral blood mononuclear cells.. AIDS. doi: 10.1097/QAD.0000000000003369.
- Marrie, RA et al.. 2022. From the prodromal stage of multiple sclerosis to disease prevention.. Nat Rev Neurol. doi: 10.1038/s41582-022-00686-x.
- Yik, JT et al.. 2022. Serum neurofilament light chain correlates with myelin and axonal magnetic resonance imaging markers in multiple sclerosis.. Mult Scler Relat Disord. doi: 10.1016/j.msard.2021.103366.
- Vavasour, IM et al.. 2022. Diffusely abnormal white matter in clinically isolated syndrome is associated with parenchymal loss and elevated neurofilament levels.. Mult Scler Relat Disord. doi: 10.1016/j.msard.2021.103422.
